Images reproduced from Surpi, A., Murgia, M., López-Amoedo, S. et al. Magnetic separation and concentration of Aβ 1–42 molecules dispersed at the threshold concentration for Alzheimer’s disease diagnosis in clinically-relevant volumes of sample. J Nanobiotechnol 21, 329 (2023)
Magnetic Technologies for Biomedical Applications
Contact: Valentin Dediu
Magnetically supported Tissue Engineering
Development of magnetically guided 3D technological platforms for the precise patterning of living cells in prototypical bio-constructs and in functional tissues. The key assembling idea is based on the ability to manipulate by remote magnetic fields cells and other bio-agents enabled with magnetic labels and perform this both in vitro and in vivo. This fast and versatile technology allows to achieve scaffold-supported and scaffold-free bio-constructs based on multiple cell types, with on-purpose and sequential arrangement in space and in time following necessary cellular architectures.
Magnetic concentration and extraction
Magnetic devices able to manipulate remotely in microfluidic environment Super-Paramagnetic nanoparticles (NP) for a wide range of diameters, including NP smaller than 10 nm. The device is based on a computerized and specifically tailored configuration of movable permanent magnets. It allows to concentrate by at least a factor of 1000 various analytes conjugated with NP.
Magnetic bio-diagnostics
Compact and portable devices built from off-the-shelf electronic components and allowing for accurate size measurement of magnetic particles with diameter below 100 nm. The sensing method is based on the measurement of the diffusion rate of MNPs in liquid by inductive coils (high concentration - µg range), by magnetoresistive sensor arrays (medium concentration – ng range), quantum sensors (low and ultralow concentrations – fg/pg range). The analysis is based on the examination of diffusivity of small NP, where their hydrodynamic radius is enhanced proportionally to the captured analyte (bio-marker, virus, environmental toxin etc.)
Selected Publications:
A Surpi et al. - Magnetic separation and concentration of Aβ 1–42 molecules dispersed at the threshold concentration for Alzheimer’s disease diagnosis in clinically-relevant volumes of sample Journal of Nanobiotechnology 21 (1), 329 (2023)
A Surpi et al. - Versatile magnetic configuration for the control and manipulation of superparamagnetic nanoparticles Scientific Reports 13 (1), 5301 (2023)
V Goranov et al. - 3D patterning of cells in magnetic scaffolds for tissue engineering Scientific reports 10 (1), 2289 (2020)